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Sigma-Aldrich Corporation was an American multinational chemical, life science and biotechnology company. In September 2014, the German company Merck announced that it would be acquiring Sigma-Aldrich for $17.0 billion, pending approval from national regulatory agencies. The acquisition was completed in 2015, and Sigma-Aldrich was merged with the Merck Millipore subsidiary of Merck, and the combined business will be known simply as Merck. Created by the 1975 merger of Sigma Chemical Company and Aldrich Chemical Company, Sigma-Aldrich since grew through various acquisitions until it had over 9,600 employees and was listed on the Fortune 1000 at the time of its acquisition by Merck. Sigma-Aldrich was headquartered in St. Louis and had operations in approximately 40 countries, which are now part of Merck.

The interview process at Sigma-Aldrich is similar to competitors. There is a common skills assessment which covers subjects including but not limited to reading, writing, speaking, and basic math. Applicants must bring their resume with them to the interview. Some applicants go through a email screening before progressing to an in person interview. Current employees have reported that it is important to show that you are capable of handling stressful situations, working in a fast paced environment, have a flexible schedule, and collaborating with others. Once through the screening process, all new hires are required to go through a introductory training.